Building on The Nebraska Medical Center’s
strong traditions in transplant and liver disease research, The Lied
Transplant Center, where much of our research takes place, facilitates
basic and clinical research by encouraging greater interaction among
researchers and health-care providers. This creates a unique atmosphere
for greater collaboration, discovery and application of new knowledge.
Clinical and basic research currently focuses
on such issues as immunosuppression, antirejection medications,
xenotransplantation, hepatocyte transplantation, liver cells and
improving treatment for hepatitis.
Clinical Research
Trials
“A Prospective, Randomized, Open
Label, Twenty-Six Week Study of the Efficacy and Safety of Converting
Kidney and Liver Transplant Recipients with Tacrolimus-Associated
Abnormal Glucose Metabolism to Neoral® with C2 Monitoring.” (Novartis)
This study is designed to determine whether
a change of immunosuppressant regimen can improve glucose metabolism
and reduce the occurrence of diabetes in post-transplant patients.
“A Phase II, Multi-Center, Randomized,
Open-Label, Dose-Ranging, Parallel Group Study of the Anti-Viral
Effects, Pharmacokinetics and Safety of Hepex-B as Compared to
Hepatitis B Immune Globulin in Patients Who Have Received Hepatic
Allografts for Hepatitis B Virus Infection.” (XTL Biopharmaceuticals,
Ltd.)
This study is evaluating an investigational
anti-viral drug for patients who received a liver transplant because
of chronic hepatitis B infection.
“A Randomized, Open-Label, Comparative
Evaluation of Conversion from Calcineurin Inhibitor Treatment to
Sirolimus Treatment Versus Continued Calcineurin Inhibitor Treatment
in Liver Allograft Recipients Undergoing Maintenance Therapy.” (Wyeth
Research)
This study is designed to determine whether
liver transplant recipients can be safely maintained on a single
anti-rejection medication, sirolimus, without the use of tacrolimus
or cyclosporine.
“A Prospective Study of Cell-Mediated
Immunity to Varicella (Chicken Pox) Following Vaccination with
Live Attenuated Varicella Virus (Varivax®) After Liver, Small
Intestine, or Combined Liver/Small Intestine Transplantation.” (No
external funding)
This study is examining the safety and effectiveness
of providing chicken pox vaccinations for patients who have received
liver and/or small intestine transplants.
“A Multi-Center Therapy Trial for
Acute Liver Failure.” (NIH)
This study is seeking to identify causes and
effective treatments for sudden onset, complete liver failure.
“SPLIT, Studies of Pediatric Liver
Transplantation, a Multicenter, Prospective Study to Collect Scientific
Data on Pediatric Liver Transplantation.” (Fujisawa)
This registry is seeking to improve the level
of care for pediatric liver transplant recipients by collecting
data across multiple centers.
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